Join

or

Existing user? Login

Use of ARBs for patients who develop angioedema following ACE inhibitor treatment

Question

UK Medicines Information summarises the evidence for this frequently asked question:

Can angiotensin II receptor blockers be taken if angioedema has occurred with ACE inhibitor treatment?

Answer

Angioedema affecting the tongue caused by ACE inhibitor treatmentAngioedema is reported to occur in 0.1–0.2% of patients who take angiotensin-converting enzyme (ACE) inhibitors. However, since ACE inhibitors are given long term and patients can develop angioedema any time during therapy, the risk may be as high as 1% for patients after 10 years of treatment.

The exact cause of angioedema associated with ACE inhibitors has not been determined. Because ACE inhibitor-induced angioedema is thought to be related to accumulation of bradykinin, it was assumed that angiotensin
II receptor blockers (ARBs) would not cause this reaction; however it has been found to occur in some patients.

The incidence of angioedema in patients receiving ARBs is uncertain but appears to be lower than in patients receiving ACE inhibitors.

There is limited evidence to suggest that a significant number of patients who develop angioedema while taking ARBs have previously experienced angioedema during ACE inhibitor therapy. The incidence of angioedema in patients switched to an ARB following ACE inhibitor-induced angioedema has been described mainly in case reports and case series, with an incidence ranging from less than 10% to greater than 50%.

Because angioedema is potentially life-threatening, ARBs should be used with extreme caution in patients who have previously experienced angioedema while receiving ACE inhibitors. The risk of recurrent angioedema should be discussed with the patient.

This FAQ is taken from a “” produced by UK Medicines Information.

Document published 16 March 2010, expires 25 February 2012

Citation: Clinical Pharmacist URI: 11004831

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Patient Care in Community Practice

    Patient Care in Community Practice is a unique, practical guide for healthcare professionals or carers. Covers a range of non-medicinal products suitable for use at home.

    £22.00
  • Clinical Pharmacokinetics

    A practical guide to the use of pharmacokinetic principles in clinical practice. Includes case studies with questions and answers.

    £33.00
  • Strategic Medicines Management

    A practical guide to influencing the availability of medicines, and policies of their use. Focuses on the strategic elements of medicines management.

    £33.00
  • Sport and Exercise Medicine for Pharmacists

    All the information you need to provide patients with evidence-based advice on sports and exercise related health matters.

    £27.00
  • Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics covers all aspects of drug use in renal failure. Shows the role of the pharmacist in patient care for chronic kidney disease.

    £38.00

Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.

levitra online bestellen

viagra generika rezeptfrei

koszt dapoksetyny