Existing user? Login

Despite facing a similar or greater risk of stroke, people with dementia are less likely to receive oral anticoagulants.

woman with dementia

Source: Shutterstock

Researchers have discovered that people with dementia are less likely to receive oral anticoagulants than those without dementia

People with atrial fibrillation (AF) who have dementia are less likely to receive oral anticoagulants (OACs) than those without cognitive impairment, research has shown[1].

The systematic review analysed 21 studies on the prevalence of OAC use in AF, involving 14,734 people with dementia or cognitive impairment and 307,961 people without.

The results showed that 32% of people with dementia received OACs, compared with 48% of those without dementia, equating to a 52% reduced odds of receiving an OAC. The researchers also said the review highlighted a lack of data on the safety and efficacy of OACs in people with dementia.

Reporting in the Journal of Alzheimer’s Disease (21 August 2018), the team said there were several possible reasons people with dementia are less likely to receive an OAC, including fear of bleeding complications, poor adherence, difficulties with self-monitoring and polypharmacy. However, previous research has suggested that dementia may be associated with an increased risk of stroke in AF.

“Studies of the safety of OAC specifically in people with AF and dementia of various types, investigating the OAC type, dose, and adherence, are urgently needed to guide treatment,” the researchers concluded.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2018.20205507

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Pharmaceutical Calculations Workbook

    Pharmaceutical Calculations Workbook contains practice calculations and answers, similar to those in pharmacy exams and in practice.

  • Health Economics

    Health Economics is a practical analysis of the prominent economic issues facing the American health care system, and what mechanisms exist to counter it.

  • Developing Your Prescribing Skills

    Developing Your Prescribing Skills uses case studies, mind maps and back from experienced prescribers. It supplies practical advice on the issues facing prescribers in all types of practice.

  • Facilitating Learning in Healthcare

    Assist learning in healthcare effectively with this practical guide. Designed specifically for people from non-teaching backgrounds.

  • Clarke's Analytical Forensic Toxicology

    All the drugs and poisons that you are most likely to encounter in forensic toxicology. Focuses on collection, extraction and analysis.


Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save

Supplementary images

  • woman with dementia ss 18