Existing user? Login

Parkinson’s disease

Study identifies biomarkers predicting cognitive decline in early Parkinson’s disease

Significant findings offer scope for the development of clinical trials and personalised treatments for Parkinson’s disease.

Cognitive impairment is a characteristic feature of Parkinson’s disease (PD), with dementia affecting up to 80% of patients long term, according to epidemiological studies.

To explore which factors predict cognitive decline, US and international researchers assessed and followed up 423 patients newly diagnosed with PD for up to three years.

The researchers found that, by year three, cognitive impairment was diagnosed in 15–38% of the participants and cognitive impairment had increased in frequency by 50–200% depending on the criteria applied.

In multivariate analysis, the researchers found that biomarker changes including dopamine deficiency, decreased global brain volume and co-morbid Alzheimer’s disease plaque pathology all independently predicted cognitive impairment. They also identified two predictive genetic markers, COMT val/val and BDNF val/val.

Reporting in PLOS ONE[1] (online, 17 May 2017), the team says the findings could help the design of future clinical trials for disease-modifying therapies and could also be a step towards personalised medicine.

Citation: Clinical Pharmacist DOI: 10.1211/CP.2017.20202935

Have your say

For commenting, please login or register as a user and agree to our Community Guidelines. You will be re-directed back to this page where you will have the ability to comment.

Recommended from Pharmaceutical Press

  • Clinical Pharmacokinetics

    A practical guide to the use of pharmacokinetic principles in clinical practice. Includes case studies with questions and answers.

  • Pharmaceutical Toxicology

    Explains the methodology and requirements of pre-clinical safety assessments of new medicines. Includes registration requirements and pharmacovigilance.

  • MCQs in Clinical Pharmacy

    Four practice tests, each with 80 practice-oriented MCQs. Assess your knowledge of clinical issues, evaluative and analytical skills.

  • Introduction to Renal Therapeutics

    Introduction to Renal Therapeutics covers all aspects of drug use in renal failure. Shows the role of the pharmacist in patient care for chronic kidney disease.

  • Pathology and Therapeutics for Pharmacists

    An practical, integrated approach to the pathophysiological and pharmacotherapeutic principles underlying the treatment of disease.


Search an extensive range of the world’s most trusted resources

Powered by MedicinesComplete
  • Print
  • Share
  • Comment
  • Save

Supplementary images

  • MRI brain scan

Newsletter Sign-up

Want to keep up with the latest news, comment and CPD articles in pharmacy and science? Subscribe to our free alerts.

amazon prime horror movies 2017

У нашей организации нужный web-сайт про направление OPTIMUM NUTRITION Gold Standard Whey оптимум нутришн голд стандарт