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Category list : Phase I research

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  • Debi Bhattacharya

    Repurposing Viagra: the ‘little blue pill’ for all ills? Subscription

    13 NOV 2018 11:46 By Rachel Brazil
    Comments (1)

    Study results suggest that PDE-5 inhibitors could have a role in treating cancer, heart failure, neurodegenerative diseases, circulatory disorders and even infectious diseases, but the road to approval for new indications may not be smooth.

  • Montage of RNAI illustration and scientists in research lab

    RNA interference therapies could be on the cusp of success Subscription

    17 MAY 2018 15:57 By Janna Lawrence

    This new way of modifying problematic gene expression has had a rocky start — but things are looking up.

  • Opium poppy historical illustration

    Pain relief: designing better opioids

    19 APR 2018 16:22 By Rachel Brazil
    Comments (1)

    While opioids are powerful painkillers, they come with dangerous side effects and carry a sometimes fatal risk of addiction. However, new, safer opioids are being developed using a variety of innovative strategies to maximise analgesic properties, while reducing the burden of side effects.

  • Immunotherapy research in diabetes concept

    Immunotherapy for type 1 diabetes: what’s in the pipeline? Subscription

    5 APR 2018 15:17 By Emma Young

    For many autoimmune diseases, such as rheumatoid arthritis and psoriasis, drugs that work by targeting components of the immune system are providing relief for millions of patients. However, there is no immunotherapy currently licensed for type 1 diabetes, and the reasons for this are multifold. A number of research groups and pharmaceutical companies are focusing on various aspects of the immune system to try to develop an effective immunotherapy for type 1 diabetes.

  • SEM of Aedes aegypti mosquito, which carries the Zika virus

    Zika vaccine development: two years on from the outbreak Subscription

    1 FEB 2018 16:00 By Brian Owens

    Two years after the World Health Organization declared the Zika virus outbreak a Public Health Emergency of International Concern, researchers have made good progress in developing vaccines against the disease, with some candidates now in phase II trials. However, the brief nature of the outbreak is making wide-scale testing of the new vaccines difficult and some research programmes have already been curtailed.

  • Huntington s disease wm 17

    First trial of Huntington’s disease drug a success

    12 DEC 2017 15:31

    The first human trial of a drug for Huntington’s disease has shown it to be safe, well-tolerated and successful in lowering the level of huntingtin protein in the nervous system. The phase I/IIa trial comprised 46 patients with early Huntington’s disease at nine study centres in the UK, Germany and Canada. Each patient received four doses of either the drug, IONIS-HTTRx, or placebo. As the trial progressed, the dose of the drug was increased ...

  • trial volunteers ss 17

    EMA publishes revised guidelines to reduce risk in first-in-human clinical trials

    27 JUL 2017 11:29

    The EMA has released revised guidance to assist sponsors of first-in-human clinical trials with the aim of reducing the risk for participants.

  • Hand holding vaccine bottle with rhinovirus vaccine (RV14)

    Rhinovirus vaccine development is about more than fighting colds Subscription

    8 JUN 2017 12:31 By Brian Owens

    Rhinovirus, the pathogen behind the common cold, can cause severe, acute lung disease in children and those with underlying respiratory conditions. Since the 1970s, vaccine development has been hindered by the presence of numerous virus serotypes and the lack of a good animal model to test vaccine candidates. However, several different research groups are now making good progress on rhinovirus vaccines, using a variety of different techniques.

  • Illustration of stem cells

    Stem cells: will they redefine stroke treatment? Subscription

    17 JAN 2017 11:30 By Dara Mohammadi

    Researchers are investigating whether stem cells can be used to restore brain tissue and reverse disability in people who have suffered a stroke, or even to stop the damage from happening in the first place. Recent trial results indicate that the field is making progress towards human application.

  • Toddler suffering from epilepsy undergoing electroencephalogram (EEG) examination

    Cannabis for epilepsy: is there enough evidence of efficacy?

    10 JAN 2017 12:08 By Michele Solis

    Parents of children with treatment-resistant epilepsy are searching for something to help, and some are turning to cannabis to try to reduce seizure frequency. With clinical trials of cannabidiol-based drugs under way, evidence for this treatment option may soon be forthcoming. However, concerns remain about side effects, such as sedation, interactions with other drugs, and potential disturbances of brain development.

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